Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation of Neuronal and Cardiovascular Signal Transduction

Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation of Neuronal and Cardiovascular Signal Transduction

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The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.In this concept, the hormone was the first messenger whose interaction with its receptor resulted in a stimulus that caused ... which then acted as the hormone messenger in eliciting the intracellular response (reviewed in Sharma et al., 1997 ). ... termed adenylate cyclase, catalyzing the formation of cyclic AMP, was a separate molecule or part, as a subunit, of the receptor. ... and underwent regulation via the oxidation-reduction potential of the biochemical reactions ( Murad et al., 1979).


Title:Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation of Neuronal and Cardiovascular Signal Transduction
Author: Rameshwar K Sharma, Wolfgang Baehr, Clint L Makino, Teresa Duda
Publisher:Frontiers Media SA - 2015-05-01
ISBN-13:

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